KLRC1 Matched Antibody Pair (674) (APMAB-674LY)

Name: KLRC1 Matched Antibody Pair (674)
SKU: APMAB-674LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-KLRC1 monoclonal antibody, 100 ug

Detection Antibody

Anti-KLRC1 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

Alternative Names

Killer Cell Lectin Like Receptor C1; Killer Cell Lectin-Like Receptor Subfamily C, Member 1; CD159 Antigen-Like Family Member A; NKG2-1/B Activating NK Receptor; NKG2-A/B-Activating NK Receptor; NK Cell Receptor A; NKG2A; NKG2-A/NKG2-B Type II Integral Membrane Protein;

Entrez Gene ID

3821

UniProt ID

P26715

More Infomation

Mac Donald, A., Guipouy, D., Lemieux, W., Harvey, M., Bordeleau, L. J., Guay, D., ... & Haddad, E. (2023). KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors. Frontiers in Immunology, 14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus, Rhesus Recombinant NKG2A protein, hFc Tag (CAT#: V2LY-0526-LY1730)

Human Recombinant NKG2A protein, ECD, His Tag (CAT#: V2LY-0526-LY5792)

Human Recombinant NKG2A protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY5793)

Human Recombinant NKG2A protein, hFc Tag (CAT#: V2LY-0526-LY5794)

Human Recombinant NKG2A protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY5795)

Mouse Recombinant NKG2A protein, His Tag (CAT#: V2LY-0526-LY8710)

Related Products

Rat Anti-KLRC1 Recombinant Antibody (AG130) (CAT#: V2LY-0524-LY157)

Mouse Anti-KLRC1 Recombinant Antibody (CBWJN-0908) (CAT#: CBMAB-N0039-WJ)

Mouse Anti-KLRC1 Recombinant Antibody (8S36) (CAT#: CBMAB-N0044-WJ)

Rabbit Anti-KLRC1 Recombinant Antibody (EG1805) (CAT#: CBMAB-EN2164-LY)

Human Recombinant NKG2A protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY5795)

Cynomolgus, Rhesus Recombinant NKG2A protein, hFc Tag (CAT#: V2LY-0526-LY1730)

Rat Anti-KLRC1 Recombinant Antibody (CBWJN-0446) (CAT#: CBMAB-N0043-WJ)

Human Anti-KLRC1 Recombinant Antibody (CBXC-0709) (CAT#: CBMAB-C1822-CQ)

Mouse Recombinant NKG2A protein, His Tag (CAT#: V2LY-0526-LY8710)

Human Recombinant NKG2A protein, ECD, His Tag (CAT#: V2LY-0526-LY5792)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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