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MARK2 Matched Antibody Pair (719) (APMAB-719LY)

This antibody pair set can be used for detecting and quantifying protein level of human MARK2.
See all MARK2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-MARK2 monoclonal antibody, 100 ug
Detection Antibody
Anti-MARK2 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Alternative Names
Microtubule Affinity Regulating Kinase 2; MAP/Microtubule Affinity-Regulating Kinase 2; ELKL Motif Kinase 1; Ser/Thr Protein Kinase PAR-1B; PAR1 Homolog B; EC 2.7.11.1; Par-1b; EMK-1; Par1b; EMK1; Serine/Threonine-Protein Kinase MARK2;
Entrez Gene ID
2011
UniProt ID
Q7KZI7

Ponnusamy, L., Natarajan, S. R., & Manoharan, R. (2022). MARK2 potentiate aerobic glycolysis‐mediated cell growth in breast cancer through regulating mTOR/HIF‐1α and p53 pathways. Journal of Cellular Biochemistry, 123(4), 759-771.

Pasapera, A. M., Heissler, S. M., Eto, M., Nishimura, Y., Fischer, R. S., Thiam, H. R., & Waterman, C. M. (2022). MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization. Current Biology, 32(12), 2704-2718.

Natarajan, S. R., Ponnusamy, L., & Manoharan, R. (2022). MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1869(7), 119242.

Zeng, Y., Yin, L., Zhou, J., Zeng, R., Xiao, Y., Black, A. R., ... & Dong, J. (2022). MARK2 regulates chemotherapeutic responses through class IIa HDAC-YAP axis in pancreatic cancer. Oncogene, 41(31), 3859-3875.

Lu, Y. N., Kavianpour, S., Zhang, T., Zhang, X., Nguyen, D., Thombre, R., ... & Wang, J. (2021). MARK2 phosphorylates eIF2α in response to proteotoxic stress. PLoS biology, 19(3), e3001096.

Wei, X., Xu, L., Jeddo, S. F., Li, K., Li, X., & Li, J. (2020). MARK2 enhances cisplatin resistance via PI3K/AKT/NF-κB signaling pathway in osteosarcoma cells. American journal of translational research, 12(5), 1807.

Xu, L., Sun, Z., Wei, X., Tan, H., Kong, P., Li, Z., ... & Li, J. (2020). The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair. Journal of Bone Oncology, 23, 100290.

Drange, O. K., Smeland, O. B., Shadrin, A. A., Finseth, P. I., Witoelar, A., Frei, O., ... & Andreassen, O. A. (2019). Genetic overlap between Alzheimer’s disease and bipolar disorder implicates the MARK2 and VAC14 genes. Frontiers in neuroscience, 13, 220.

Ichinose, S., Ogawa, T., Jiang, X., & Hirokawa, N. (2019). The spatiotemporal construction of the axon initial segment via KIF3/KAP3/TRIM46 transport under MARK2 signaling. Cell Reports, 28(9), 2413-2426.

DiBona, V. L., Zhu, W., Shah, M. K., Rafalia, A., Ben Cheikh, H., Crockett, D. P., & Zhang, H. (2019). Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury. Journal of neuroinflammation, 16, 1-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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