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Mouse Anti-ADGRE4P Recombinant Antibody (V2-619772) (CBMAB-A2590-LY)

The product is antibody recognizes EMR4. The antibody 2H8 immunoassay techniques such as: WB, ELISA.
See all ADGRE4P antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-619772
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
EMR4 (XP_377506, 21 a.a. ~ 93 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor E4, Pseudogene
Introduction
This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq]
Entrez Gene ID
326342
UniProt ID
Q86SQ3
Alternative Names
EMR4; FIRE; GPR127; PGR16
Function
May mediate the cellular interaction between myeloid cells and B-cells.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 16-191 aa
Helical: 192-212 aa
Cytoplasmic: 213-223 aa
Helical: 224-244 aa
Extracellular: 245-250 aa
Helical: 251-271 aa
Cytoplasmic: 272-299 aa
Helical: 300-320 aa
Extracellular: 321-336 aa
Helical: 337-357 aa
Cytoplasmic: 358-384 aa
Helical: 385-405 aa
Extracellular: 406-413 aa
Helical: 414-434 aa
Cytoplasmic: 435-457 aa
PTM
Glycosylated.
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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