ADGRE4P

This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]

Full Name

Adhesion G Protein-Coupled Receptor E4, Pseudogene

Function

May mediate the cellular interaction between myeloid cells and B-cells.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted

Topology

Extracellular: 16-191 aa
Helical: 192-212 aa
Cytoplasmic: 213-223 aa
Helical: 224-244 aa
Extracellular: 245-250 aa
Helical: 251-271 aa
Cytoplasmic: 272-299 aa
Helical: 300-320 aa
Extracellular: 321-336 aa
Helical: 337-357 aa
Cytoplasmic: 358-384 aa
Helical: 385-405 aa
Extracellular: 406-413 aa
Helical: 414-434 aa
Cytoplasmic: 435-457 aa

PTM

Glycosylated.
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.