Mouse Anti-AK5 Recombinant Antibody (V2-180428) (CBMAB-A1900-YC)

Name: Mouse Anti-AK5 Recombinant Antibody (V2-180428)
SKU: CBMAB-A1900-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180428

Application

IHC-F, ICC, IF, IHC, IHC-P, WB

Immunogen

Full length human recombinant protein of human AK5 (NP_777283) produced in HEK293T cell

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:2,000
IHC	1:150
IF(ICC)	1:100
FC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, PH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

adenylate kinase 5

Introduction

AK5 is a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kin

Entrez Gene ID

26289

UniProt ID

Q9Y6K8

Alternative Names

Adenylate Kinase 5; ATP-AMP Transphosphorylase 5; AK 5; Adenylate Kinase Isoenzyme 5; Adenylate Kinase 6; EC 2.7.4.3; EC 2.7.4.6; AK6;

Function

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.

Biological Process

ADP biosynthetic process Source: ProtInc
ATP metabolic process Source: InterPro
dADP biosynthetic process Source: ProtInc
Nucleobase-containing small molecule interconversion Source: Reactome
Nucleoside diphosphate phosphorylation Source: UniProtKB
Nucleoside triphosphate biosynthetic process Source: UniProtKB
Pyrimidine ribonucleotide biosynthetic process Source: ProtInc

Cellular Location

Cytoplasm

Ahn, B., Chae, Y. S., Lee, S. K., Kim, M., Kim, H. S., Moon, J. W., & Park, S. H. (2021). Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma. Scientific reports, 11(1), 1-13.

Vicino, A., Loser, V., Chiabotti, P. S., Brouland, J. P., & Du Pasquier, R. (2021). Anti-Adenylate Kinase 5 Encephalitis With Histologic Evidence of CNS Vasculitis. Neurology® Neuroimmunology & Neuroinflammation, 8(4).

Muñiz-Castrillo, S., Hedou, J. J., Ambati, A., Jones, D., Vogrig, A., Pinto, A. L., ... & Honnorat, J. (2021). Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis. Brain.

Bien, C. I., Nehls, F., Kollmar, R., Weis, M., Steinke, W., Woermann, F., ... & Bien, C. G. (2019). Identification of adenylate kinase 5 antibodies during routine diagnostics in a tissue-based assay: three new cases and a review of the literature. Journal of neuroimmunology, 334, 576975.

Do, L. D., Chanson, E., Desestret, V., Joubert, B., Ducray, F., Brugière, S., ... & Honnorat, J. (2017). Characteristics in limbic encephalitis with anti–adenylate kinase 5 autoantibodies. Neurology, 88(6), 514-524.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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