Mouse Anti-AKIRIN2 Recombinant Antibody (V2-180446) (CBMAB-A1954-YC)

Name: Mouse Anti-AKIRIN2 Recombinant Antibody (V2-180446)
SKU: CBMAB-A1954-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-180446

Application

ELISA, IF, WB

Immunogen

Full length recombinant corresponding to aa1-204 from human C6orf166 (AAH00764) with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Akirin 2

Introduction

AKIRIN2 is required for the innate immune response and is a downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. AKIRIN2 forms a complex with YWHAB that acts to repress transcription

Entrez Gene ID

55122

UniProt ID

Q53H80

Alternative Names

Akirin 2; C6orf166; Fourteen-Three-Three Beta Interactant 1; Chromosome 6 Open Reading Frame 166; DJ486L4.2; Akirin-2; FBI1;

Function

Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).

Biological Process

Embryo development ending in birth or egg hatching Source: Ensembl
Innate immune response Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of endopeptidase activity Source: Ensembl
Positive regulation of innate immune response Source: GO_Central
Positive regulation of interleukin-6 production Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Response to lipopolysaccharide Source: Ensembl

Cellular Location

Nucleus

Artigas-Jerónimo, S., Villar, M., Estrada-Peña, A., Velázquez-Campoy, A., Alberdi, P., & de la Fuente, J. (2021). Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells. Bioscience reports, 41(7), BSR20211120.

Peek, S. L., Bosch, P. J., Bahl, E., Iverson, B. J., Parida, M., Bais, P., ... & Weiner, J. A. (2021). p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2. bioRxiv.

Zeng, M., Qu, K., Hanif, Q., Liu, J., Zhang, J., Chen, N., ... & Lei, C. (2020). Distribution of the variant at AKIRIN2: c.* 188G> A in Chinese cattle. Animal Biotechnology, 1-5.

Li, Y., Cheng, G., Zhao, Y., Bai, C., Wang, S., Wu, K., ... & Tong, B. (2020). SNPs in AKIRIN2, TTN, EDG1 and MYBPC1 genes are associated with growth-related traits in Chinese Qinchuan cattle.

Bosch, P. J., Fuller, L. C., & Weiner, J. A. (2019). A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo. genesis, 57(5), e23286.

Leng, K., Xu, Y., Kang, P., Qin, W., Cai, H., Wang, H., ... & Cui, Y. (2019). Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway. Cell death & disease, 10(4), 1-15.

Anwar, S., Wulandari, A. S., Putra, W. P. B., & Said, S. (2019). The The favorable alleles of AKIRIN2: c.* 188G> A, EDG1: c.-312A> G and TTN: g. 231054C> T as candidate markers for high-marbling are very low in Bali cattle. Biodiversitas Journal of Biological Diversity, 20(4), 965-970.

Bosch, P. J., Fuller, L. C., & Weiner, J. A. (2018). An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression. Scientific reports, 8(1), 1-12.

Liu, X., Xia, Y., Tang, J., Ma, L., Li, C., Ma, P., & Mao, B. (2017). Dual roles of Akirin2 protein during Xenopus neural development. Journal of Biological Chemistry, 292(14), 5676-5684.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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