Mouse Anti-GPRASP2 Recombinant Antibody (7H70) (V2LY-0226-LY912)

Name: Mouse Anti-GPRASP2 Recombinant Antibody (7H70)
SKU: V2LY-0226-LY912
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

7H70

Application

ELISA, IP, IF, WB

Immunogen

Amino acids 272-297 of human GASP-2.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

G Protein-Coupled Receptor Associated Sorting Protein 2

Entrez Gene ID

114928

UniProt ID

Q96D09

Function

May play a role in regulation of a variety of G-protein coupled receptors.

Biological Process

Hematopoietic stem cell homeostasis Source: Ensembl

Cellular Location

Nucleus; Cytoplasm

Involvement in disease

Deafness, X-linked, 7 (DFNX7):
A congenital form of bilateral mixed or conductive hearing loss, which is progressive in some patients. Additional clinical features include ear anomalies and facial dysmorphism with bilateral ptosis.

Nevitt, C., Kelley, Z., Kooienga, E., Briu, L. M., & McKinney-Freeman, S. (2022). 3147–IMPROVED HUMAN HEMATOPOIETIC STEM CELL TRANSPLANTATION BY TARGETING OF GPRASP2. Experimental Hematology, 111, S118.

Lu, Y., Zhang, M., Wei, Q., Chen, Z., Xing, G., Yao, J., & Cao, X. (2021). Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells. Biochemical and Biophysical Research Communications, 574, 1-7.

Nevitt, C., & McKinney-Freeman, S. (2020). 3117–GPRASP2 REGULATES CXCR4 STABILITY AND SIGNAL TRANSDUCTION IN HUMAN HEMATOPOIETIC CELLS WITH IMPLICATIONS FOR HSPC TRANSPLANTATION. Experimental Hematology, 88, S74.

Edfawy, M., Guedes, J. R., Pereira, M. I., Laranjo, M., Carvalho, M. J., Gao, X., ... & Peça, J. (2019). Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice. Nature communications, 10(1), 1431.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GPRASP2 Recombinant Antibody (G0725) (CAT#: V2LY-0226-LY911)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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