Mouse Recombinant TLR8 protein, hFc Tag (V2LY-0526-LY8991)

TLR8 Gene(Protein Coding) Toll Like Receptor 8

Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612).
Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653).
Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825).
Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825).
In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).

Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process defense response to virusSource:UniProtKB1 Publication
Biological Process I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process immunoglobulin mediated immune responseSource:UniProtKB1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process innate immune responseSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process negative regulation of interleukin-12 productionSource:CAFA1 Publication
Biological Process positive regulation of innate immune responseSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-alpha productionSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-beta productionSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-gamma productionSource:UniProtKB1 Publication
Biological Process positive regulation of interleukin-1 beta productionSource:UniProtKB1 Publication
Biological Process positive regulation of interleukin-6 productionSource:CAFA1 Publication
Biological Process positive regulation of interleukin-8 productionSource:UniProtKB1 Publication
Biological Process regulation of protein phosphorylationSource:Ensembl
Biological Process response to virusSource:UniProtKB1 Publication
Biological Process toll-like receptor 8 signaling pathwaySource:UniProtKB1 Publication
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication

Endosome membrane
Endosomal localization confers distinctive proteolytic processing.

Extracellular: 27-827
Helical: 828-848
Cytoplasmic: 849-1041

Ubiquitinated by RNF216; leading to degradation by the proteasome.
Proteolytic processing occurs in monocytes and monocyte-derived macrophages by both furin-like proprotein convertase and cathepsins (PubMed:25297876).
The cleavage is necessary for dimer formation and subsequent activation (PubMed:26929371).