Mouse Recombinant VDR protein, His Tag (V2LY-0526-LY9070)

VDR

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179).
Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609).
The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609).
Plays a central role in calcium homeostasis (By similarity).

Biological Process apoptotic process involved in mammary gland involution Source:Ensembl
Biological Process bile acid signaling pathway Source:UniProtKB1 Publication
Biological Process calcium ion transport Source:Ensembl
Biological Process cell differentiation Source:GO_Central1 Publication
Biological Process cell morphogenesis Source:UniProtKB1 Publication
Biological Process cellular calcium ion homeostasis Source:Ensembl
Biological Process decidualization Source:BHF-UCL1 Publication
Biological Process intestinal absorption Source:Ensembl
Biological Process lactation Source:Ensembl
Biological Process mammary gland branching involved in pregnancy Source:Ensembl
Biological Process mRNA transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process negative regulation of cell population proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of DNA-templated transcription Source:MGI1 Publication
Biological Process negative regulation of keratinocyte proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of apoptotic process involved in mammary gland involution Source:Ensembl
Biological Process positive regulation of bone mineralization Source:ComplexPortal1 Publication
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process positive regulation of vitamin D 24-hydroxylase activity Source:BHF-UCL1 Publication
Biological Process positive regulation of vitamin D receptor signaling pathway Source:ComplexPortal1 Publication
Biological Process regulation of calcidiol 1-monooxygenase activity Source:BHF-UCL
Biological Process skeletal system development Source:Ensembl
Biological Process vitamin D receptor signaling pathway Source:BHF-UCL1 Publication

Nucleus
Cytoplasm
Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331).
Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4 (PubMed:16207705).

Rickets vitamin D-dependent 2A (VDDR2A):
A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.