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NKX2-5 Matched Antibody Pair (801) (APMAB-801LY)

This antibody pair set can be used for detecting and quantifying protein level of human NKX2-5.
See all NKX2-5 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NKX2-5 polyclonal antibody, 100 ug
Detection Antibody
Anti-NKX2-5 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Alternative Names
NK2 Homeobox 5; Homeobox Protein NK-2 Homolog E; Homeobox Protein CSX; NKX2.5; NKX2E; CSX; NK2 Transcription Factor Related, Locus 5 (Drosophila); NK2 Transcription Factor Related, Locus 5; Tinman Paralog (Drosophila); Cardiac-Specific Homeobox 1; Cardiac-Specific Homeo Box;
Entrez Gene ID
1482
UniProt ID
P52952

Cao, C., Li, L., Zhang, Q., Li, H., Wang, Z., Wang, A., & Liu, J. (2023). Nkx2. 5: a crucial regulator of cardiac development, regeneration and diseases. Frontiers in Cardiovascular Medicine, 10.

de Sena-Tomás, C., Aleman, A. G., Ford, C., Varshney, A., Yao, D., Harrington, J. K., ... & Targoff, K. L. (2022). Activation of Nkx2. 5 transcriptional program is required for adult myocardial repair. Nature Communications, 13(1), 2970.

Feng, W., Schriever, H., Jiang, S., Bais, A., Wu, H., Kostka, D., & Li, G. (2022). Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency. Communications Biology, 5(1), 399.

Dixit, R., Narasimhan, C., Balekundri, V. I., Agrawal, D., Kumar, A., & Mohapatra, B. (2021). Functional analysis of novel genetic variants of NKX2‐5 associated with nonsyndromic congenital heart disease. American Journal of Medical Genetics Part A, 185(12), 3644-3663.

Kolomenski, J. E., Delea, M., Simonetti, L., Fabbro, M. C., Espeche, L. D., Taboas, M., ... & Dain, L. (2020). An update on genetic variants of the NKX2‐5. Human Mutation, 41(7), 1187-1208.

Ren, J., Han, P., Ma, X., Farah, E. N., Bloomekatz, J., Zeng, X. X. I., ... & Chi, N. C. (2019). Canonical Wnt5b signaling directs outlying Nkx2. 5+ mesoderm into pacemaker cardiomyocytes. Developmental cell, 50(6), 729-743.

Benaglio, P., D’Antonio-Chronowska, A., Ma, W., Yang, F., Young Greenwald, W. W., Donovan, M. K., ... & Frazer, K. A. (2019). Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits. Nature genetics, 51(10), 1506-1517.

Behiry, E. G., Al‐Azzouny, M. A., Sabry, D., Behairy, O. G., & Salem, N. E. (2019). Association of NKX2‐5, GATA4, and TBX5 polymorphisms with congenital heart disease in Egyptian children. Molecular Genetics & Genomic Medicine, 7(5), e612.

Kalayinia, S., Ghasemi, S., & Mahdieh, N. (2019). A comprehensive in silico analysis, distribution and frequency of human Nkx2-5 mutations; A critical gene in congenital heart disease. Journal of cardiovascular and thoracic research, 11(4), 287.

Dupays, L., Towers, N., Wood, S., David, A., Stuckey, D. J., & Mohun, T. (2019). Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function. PLoS One, 14(3), e0212992.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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