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Mouse Anti-NR2C2 Recombinant Antibody (3G1-C4-E10) (CBMAB-Z0409-LY)

The product is antibody recognizes TAK1. The antibody 3G1-C4-E10 immunoassay techniques such as: WB.
See all NR2C2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
3G1-C4-E10
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Purified recombinant human TAK1 protein fragments expressed in E.coli.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nuclear Receptor Subfamily 2 Group C Member 2
Entrez Gene ID
Human7182
Mouse22026
Rat50659
Monkey703135
UniProt ID
HumanP49116
MouseP49117
RatP55094
MonkeyE1B9Y6
Alternative Names
CSCF; FMD2; TAK1; MEKK7; TGF1a
Function
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity).
Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIPI:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of embryonic developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
SpermatogenesisIEA:UniProtKB-KW
Cellular Location
Nucleus
PTM
Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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