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PCK1 Matched Antibody Pair (847) (APMAB-847LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-PCK1 polyclonal antibody, 100 ug
Detection Antibody
Anti-PCK1 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Alternative Names
Phosphoenolpyruvate Carboxykinase 1; Phosphoenolpyruvate Carboxykinase 1 (Soluble); EC 4.1.1.32; PEPCK-C; PEPCK1; Phosphoenolpyruvate Carboxykinase, Cytosolic [GTP]; Phosphoenolpyruvate Carboxykinase, Cytosolic;
Entrez Gene ID
5105
UniProt ID
P35558
More Infomation

Xue, S., Cai, Y., Liu, J., Ji, K., Yi, P., Long, H., ... & Song, Y. (2024). Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis. Cellular Signalling, 120, 111198.

Lu, K., Wu, J., Zhang, Y., Zhuang, W., & Liang, X. F. (2023). Role of phosphoenolpyruvate carboxykinase 1 (pck1) in mediating nutrient metabolism in zebrafish. Functional & Integrative Genomics, 23(1), 67.

Gonzalez-Rellan, M. J., Fernández, U., Parracho, T., Novoa, E., Fondevila, M. F., da Silva Lima, N., ... & Nogueiras, R. (2023). Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism. Cell metabolism, 35(9), 1630-1645.

Yao, J., Wu, X. Y., Yu, Q., Yang, S. F., Yuan, J., Zhang, Z. Q., ... & Cao, C. (2022). The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo. Science Advances, 8(21), eabn6928.

Zhu, X. R., Peng, S. Q., Wang, L., Chen, X. Y., Feng, C. X., Liu, Y. Y., & Chen, M. B. (2021). Identification of phosphoenolpyruvate carboxykinase 1 as a potential therapeutic target for pancreatic cancer. Cell Death & Disease, 12(10), 918.

Latorre-Muro, P., Baeza, J., Hurtado-Guerrero, R., Hicks, T., Delso, I., Hernández-Ruiz, C., ... & Carrodeguas, J. A. (2021). Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. Journal of Biological Chemistry, 296.

Yu, S., Meng, S., Xiang, M., & Ma, H. (2021). Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis. Molecular metabolism, 53, 101257.

Geng, X., Shen, J., Li, F., Yip, J., Guan, L., Rajah, G., ... & Ding, Y. (2021). Phosphoenolpyruvate carboxykinase (PCK) in the brain gluconeogenic pathway contributes to oxidative and lactic injury after stroke. Molecular Neurobiology, 58, 2309-2321.

Westermeier, F., Holyoak, T., Gatica, R., Martinez, F., Negron, M., Yanez, A. J., ... & Bertinat, R. (2020). Cytosolic phosphoenolpyruvate carboxykinase is expressed in α‐cells from human and murine pancreas. Journal of Cellular Physiology, 235(1), 166-175.

Seenappa, V., Joshi, M. B., & Satyamoorthy, K. (2019). Intricate regulation of phosphoenolpyruvate carboxykinase (PEPCK) isoforms in normal physiology and disease. Current Molecular Medicine, 19(4), 247-272.

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For research use only. Not intended for any clinical use.

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