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PDCD6IP Matched Antibody Pair (854) (APMAB-854LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-PDCD6IP monoclonal antibody, 100 ug
Detection Antibody
Anti-PDCD6IP Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
Alternative Names
Programmed Cell Death 6 Interacting Protein; Programmed Cell Death 6-Interacting Protein; ALG-2-Interacting Protein X; PDCD6-Interacting Protein; AIP1; HP95; ALIX; Apoptosis-Linked Gene 2-Interacting Protein X;
Entrez Gene ID
10015
UniProt ID
Q8WUM4
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For research use only. Not intended for any clinical use.

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