Sign in or Register   Sign in or Register
  |  

Mouse Anti-PSMB8/LMP7 Recombinant Antibody (3G3-C1-E2) (CBMAB-Z0367-LY)

The product is antibody recognizes PSMB8/LMP7. The antibody 3G3-C1-E2 immunoassay techniques such as: WB, IHC, ICC.
See all PSMB8/LMP7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
3G3-C1-E2
Antibody Isotype
IgG1
Application
WB, IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human PSMB8 expressed in E. Coli.
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
Entrez Gene ID
Human5696
Rat24968
UniProt ID
HumanP28062
RatP28064
Alternative Names
JMP; LMP7; D6S216; PSMB5i; RING10; D6S216E; MGC1491
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).
Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.
Biological Process
Antigen processing and presentationIEA:Ensembl
Fat cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Proteasomal protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of endopeptidase activityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Proteasome-associated autoinflammatory syndrome 1 (PRAAS1):
An autosomal recessive autoinflammatory disorder characterized by early childhood onset of recurrent fever, joint stiffness and severe contractures of the hands and feet, and erythematous skin lesions with subsequent development of lipodystrophy and laboratory evidence of immune dysregulation. Accompanying features may include muscle weakness and atrophy, hepatosplenomegaly, and microcytic anemia.
PTM
Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PSMB8/LMP7 Recombinant Antibody (3G3-C1-E2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare