Rat Gps1 ELISA Kit (V2LY-0626-LY1471)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.03 ng/mL
Detection Range
0.05-30 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
53.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
G protein pathway suppressor 1
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Biological Process
Inactivation of MAPK activity Source: ProtInc
JNK cascade Source: ProtInc
Protein deneddylation Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm

Horváth, A., Rona, G., Pagano, M., & Jordan, P. W. (2020). Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome. BMC Molecular and Cell Biology, 21(1), 1-10.

Kuwahara, T., Yamayoshi, S., Noda, T., & Kawaoka, Y. (2019). G Protein Pathway Suppressor 1 Promotes Influenza Virus Polymerase Activity by Activating the NF-κB Signaling Pathway. Mbio, 10(6), e02867-19.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-GPS1 Recombinant Antibody (CBWJC-3746) (CAT#: CBMAB-C5011WJ)

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For research use only. Not intended for any clinical use.

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