Rat Prps1 ELISA Kit (V2LY-0626-LY2616)

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Tested Data
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0054 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
34.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Phosphoribosyl Pyrophosphate Synthetase 1
Function
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Biological Process
5-phosphoribose 1-diphosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Hypoxanthine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentIMP:UniProtKB
PhosphorylationIEA:UniProtKB-KW
Purine nucleobase metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Purine nucleotide biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Pyrimidine nucleotide biosynthetic process1 PublicationNAS:UniProtKB
Ribonucleoside monophosphate biosynthetic processIEA:InterPro
Urate biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
cytoplasm
cytosol
ribose phosphate diphosphokinase complex
Involvement in disease
Phosphoribosylpyrophosphate synthetase superactivity (PRPS1 superactivity):
Familial disorder characterized by excessive purine production, gout and uric acid urolithiasis.
Charcot-Marie-Tooth disease, X-linked recessive, 5 (CMTX5):
A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy.
ARTS syndrome (ARTS):
A disorder characterized by intellectual disability, early-onset hypotonia, ataxia, delayed motor development, hearing impairment, and optic atrophy. Susceptibility to infections, especially of the upper respiratory tract, can result in early death.
Deafness, X-linked, 1 (DFNX1):
A form of deafness characterized by progressive, severe-to-profound sensorineural hearing loss in males. Females manifest mild to moderate hearing loss.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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