Rat Recombinant TNFRSF21 protein, hFc Tag (V2LY-0526-LY9337)

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Datasheet
SDS
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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Rat
Tag
hFc Tag
Protein Construction
This product is Rat Recombinant TNFRSF21 protein, hFc Tag consist of Amino Acid: 1-349 and predicts a molecular mass of 60.5 kDa.
Molecule Mass
60.5 kDa
Sequence
Amino Acid: 1-349
Species
Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>90% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TNFRSF21 Gene(Protein Coding) TNF Receptor Superfamily Member 21
Function
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
Biological Process
Biological Process adaptive immune response Source:UniProtKB
Biological Process apoptotic process Source:UniProtKB1 Publication
Biological Process axonal fasciculation Source:Ensembl
Biological Process B cell apoptotic process Source:UniProtKB
Biological Process cellular response to tumor necrosis factor Source:UniProtKB1 Publication
Biological Process humoral immune response Source:UniProtKB
Biological Process myelination Source:UniProtKB
Biological Process negative regulation of B cell proliferation Source:UniProtKB
Biological Process negative regulation of interleukin-10 production Source:UniProtKB
Biological Process negative regulation of interleukin-13 production Source:UniProtKB
Biological Process negative regulation of interleukin-5 production Source:UniProtKB
Biological Process negative regulation of myelination Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB
Biological Process neuron apoptotic process Source:UniProtKB
Biological Process oligodendrocyte apoptotic process Source:UniProtKB
Biological Process regulation of oligodendrocyte differentiation Source:UniProtKB
Biological Process T cell receptor signaling pathway Source:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 42-349
Helical: 350-370
Cytoplasmic: 371-655
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TNFRSF21 protein (CAT#: V2LY-0526-LY3646)

Human Recombinant TNFRSF21 protein, hFc Tag (CAT#: V2LY-0526-LY3647)

Human Recombinant TNFRSF21 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY3648)

Human Recombinant TNFRSF21 protein, His Tag (CAT#: V2LY-0526-LY3649)

Cynomolgus Recombinant TNFRSF21 protein, His Tag (CAT#: V2LY-0526-LY1489)

Mouse Recombinant TNFRSF21 protein, His Tag (CAT#: V2LY-0526-LY8214)

TNFRSF21 Matched Antibody Pair (1235) (CAT#: APMAB-1235LY)

Antibody Pairs

TNFRSF21 Matched Antibody Pair (1235) (CAT#: APMAB-1235LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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