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RNASEH2A Matched Antibody Pair (1002) (APMAB-1002LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-RNASEH2A polyclonal antibody, 100 ug
Detection Antibody
Anti-RNASEH2A Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
Alternative Names
Ribonuclease H2 Subunit A; Aicardi-Goutieres Syndrome 4 Protein; Ribonuclease H2, Large Subunit; Ribonuclease HI Large Subunit; Ribonuclease HI Subunit A; RNase HI Large Subunit; RNase H2 Subunit A; RNase H(35); EC 3.1.26.4;
Entrez Gene ID
10535
UniProt ID
O75792
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For research use only. Not intended for any clinical use.

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