ABCA5

ABCA5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2

Full Name

ATP Binding Cassette Subfamily A Member 5

Function

Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes (By similarity).

Biological Process

Cholesterol efflux
Cholesterol homeostasis
Cholesterol metabolic process
High-density lipoprotein particle remodeling
Lipid transport
Negative regulation of macrophage derived foam cell differentiation
Positive regulation of reverse cholesterol transport
Regulation of cholesterol efflux
Reverse cholesterol transport

Cellular Location

Cell membrane; Late endosome membrane; Golgi apparatus membrane; Lysosome membrane. Localized at cell membrane under high cholesterol levels.

PTM

N-glycosylated.