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NTRK2

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Full Name
Neurotrophic Receptor Tyrosine Kinase 2
Function
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity).
Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731).
Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731).
Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Biological Process
Brain-derived neurotrophic factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to amino acid stimulusIEA:Ensembl
Cellular response to brain-derived neurotrophic factor stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system neuron developmentISS:UniProtKB
Cerebral cortex developmentISS:UniProtKB
Circadian rhythmIEA:Ensembl
Feeding behaviorIEA:Ensembl
Glutamate secretionIEA:Ensembl
LearningISS:UniProtKB
Long-term synaptic potentiationIEA:Ensembl
Mechanoreceptor differentiationIEA:Ensembl
Myelination in peripheral nervous systemIEA:Ensembl
Negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of anoikisIEA:Ensembl
Negative regulation of neuron apoptotic processISS:UniProtKB
Neuron differentiationISS:UniProtKB
Neuron migrationISS:UniProtKB
Neuronal action potential propagationIEA:Ensembl
Oligodendrocyte differentiationIEA:Ensembl
Peripheral nervous system neuron developmentIEA:Ensembl
Positive regulation of axonogenesisISS:UniProtKB
Positive regulation of cell population proliferationISS:UniProtKB
Positive regulation of gene expressionISS:UniProtKB
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of MAPK cascadeISS:UniProtKB
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of peptidyl-serine phosphorylationIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingISS:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of synapse assemblyIEA:Ensembl
Protein autophosphorylationISS:UniProtKB
Regulation of GTPase activityISS:UniProtKB
Regulation of protein kinase B signalingManual Assertion Based On ExperimentIBA:GO_Central
Retinal rod cell developmentIEA:Ensembl
Trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl
Trans-synaptic signaling by neuropeptide, modulating synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
VasculogenesisIEA:Ensembl
Cellular Location
Cell membrane
Endosome membrane
Early endosome membrane
Cell projection, axon
Cell projection, dendrite
Cytoplasm, perinuclear region
Cell junction, synapse, postsynaptic density
Internalized to endosomes upon ligand-binding.
Involvement in disease
Developmental and epileptic encephalopathy 58 (DEE58):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life.
Obesity, hyperphagia, and developmental delay (OBHD):
A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language.
Topology
Extracellular: 32-430
Helical: 431-454
Cytoplasmic: 455-822
PTM
Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).

Anti-NTRK2 antibodies

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Target: NTRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0120
Application*: P, IP, WB
Target: NTRK2 (phospho Y706)
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0184
Application*: DB, WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0586-7Y6
Application*: WB, P
Target: NTRK2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJT-1532
Application*: WB, IH
Target: NTRK2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-1531
Application*: IH, WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1530
Application*: WB, IH, IC, IF, P
Target: NTRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-1529
Application*: E, WB, P
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1528
Application*: WB, F, E, IH, IC, MC
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1527
Application*: E, EC, F
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1526
Application*: WB, IH
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1525
Application*: F, MC
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1524
Application*: WB, E, IH, P
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.A.37
Application*: E, IP, WB
Target: NTRK2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJN-0843
Application*: WB, IH
Target: NTRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1587
Application*: WB, IP, P
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: A15019C
Application*: WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJN-0414
Application*: E, WB
Target: NTRK2
Host: Mouse
Specificity: Human
Clone: 3D12
Application*: E, WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: 2A7F11
Application*: E, WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1446CT494.85.83.49
Application*: WB, P
Target: NTRK2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBWJN-1586
Application*: C, WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1585
Application*: IH, WB
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1584
Application*: F, WB, E
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: 2E1
Application*: IH, WB
Target: NTRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 80G2
Application*: P, F
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb233
Application*: WB, IH, FC
Target: NTRK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D3-F10
Application*: WB, E
Target: NTRK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EPR17805-146
Application*: P, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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