ADAM11

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq]

ADAM metallopeptidase domain 11

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Integrin-mediated signaling pathway

Membrane

Extracellular: 226-734 aa
Helical: 735-755 aa
Cytoplasmic: 756-769 aa

The precursor is cleaved by a furin endopeptidase.