ADGRL2

ADGRL2 is a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis

Full Name

Adhesion G Protein-Coupled Receptor L2

Function

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Positive regulation of synapse assembly
Response to bacterium
Synapse organization

Cellular Location

Membrane

Topology

Extracellular: 26-851 aa
Helical: 852-872 aa
Cytoplasmic: 873-880 aa
Helical: 881-901 aa
Extracellular: 902-907 aa
Helical: 908-928 aa
Cytoplasmic: 929-952 aa
Helical: 953-973 aa
Extracellular: 974-990 aa
Helical: 991-1011 aa
Cytoplasmic: 1012-1037 aa
Helical: 1038-1058 aa
Extracellular: 1059-1062 aa
Helical: 1063-1083 aa
Cytoplasmic: 1084-1459 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

Anti-ADGRL2 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-ADGRL2 Recombinant Antibody (V2-58650) (CBMAB-L0301-YJ)

Datasheet

SDS

Target: ADGRL2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: V2-58650

Application*: FC, WB

Mouse Anti-ADGRL2 Recombinant Antibody (V2-58519) (CBMAB-L0166-YJ)

Datasheet

SDS

Target: ADGRL2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-58519

Application*: WB, IP, IF, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)