ADGRL2

ADGRL2 is a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis

Full Name

Adhesion G Protein-Coupled Receptor L2

Function

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Positive regulation of synapse assembly
Response to bacterium
Synapse organization

Cellular Location

Membrane

Topology

Extracellular: 26-851 aa
Helical: 852-872 aa
Cytoplasmic: 873-880 aa
Helical: 881-901 aa
Extracellular: 902-907 aa
Helical: 908-928 aa
Cytoplasmic: 929-952 aa
Helical: 953-973 aa
Extracellular: 974-990 aa
Helical: 991-1011 aa
Cytoplasmic: 1012-1037 aa
Helical: 1038-1058 aa
Extracellular: 1059-1062 aa
Helical: 1063-1083 aa
Cytoplasmic: 1084-1459 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.