Mouse Anti-ADGRL2 Recombinant Antibody (V2-58650) (CBMAB-L0301-YJ)

Name: Mouse Anti-ADGRL2 Recombinant Antibody (V2-58650)
SKU: CBMAB-L0301-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-58650

Application

FC, WB

Immunogen

Human Latrophilin 2/LPHN2 synthetic peptide

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 μg/ml
FC	0.25 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-202

More Infomation

Target

Full Name

Adhesion G Protein-Coupled Receptor L2

Introduction

ADGRL2 is a member of the latrophilin subfamily of G-protein coupled receptors. ADGRL2 participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

23266

UniProt ID

O95490

Alternative Names

Adhesion G Protein-Coupled Receptor L2; Calcium-Independent Alpha-Latrotoxin Receptor 2; Latrophilin Homolog 1; Latrophilin-2; Lectomedin-1; LPHH1; LPHN2; LEC1

Function

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Brain development
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Positive regulation of synapse assembly
Response to bacterium
Synapse organization

Cellular Location

Membrane

Topology

Extracellular: 26-851 aa
Helical: 852-872 aa
Cytoplasmic: 873-880 aa
Helical: 881-901 aa
Extracellular: 902-907 aa
Helical: 908-928 aa
Cytoplasmic: 929-952 aa
Helical: 953-973 aa
Extracellular: 974-990 aa
Helical: 991-1011 aa
Cytoplasmic: 1012-1037 aa
Helical: 1038-1058 aa
Extracellular: 1059-1062 aa
Helical: 1063-1083 aa
Cytoplasmic: 1084-1459 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

Bucar, E., McWilliams, C., & Frey, M. (2020). Adhesion G‐Protein‐Coupled Receptor L2 Expression is Lost in Colorectal Cancer but is Also Associated with Colonic Stem Cells. The FASEB Journal, 34(S1), 1-1.

Kang, H. C., Kim, H. S., Lee, J. B., Yoo, C. K., Choi, T. J., & Lim, H. T. (2018). Analysis of the relationship between the end weight trait and the gene ADGRL2 in purebred landrace pigs using a Genome-wide association study. Korean Journal of Agricultural Science, 45(2), 238-247.

Vezain, M., Lecuyer, M., Rubio, M., Dupé, V., Ratié, L., David, V., ... & Saugier-Veber, P. (2018). A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis. Acta neuropathologica communications, 6(1), 1-23.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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