ADRA1A

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Adrenoceptor Alpha 1A

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

Activation of phospholipase C activity
Adenylate cyclase-activating adrenergic receptor signaling pathway
Adult heart development
Aging
Apoptotic process
Calcium ion transport into cytosol
Cell-cell signaling
Cell growth involved in cardiac muscle cell development
G protein-coupled receptor signaling pathway
Intracellular signal transduction
Micturition
Negative regulation of autophagy
Negative regulation of cell population proliferation
Negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
Negative regulation of Rho protein signal transduction
Neuron-glial cell signaling
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
Phospholipase C-activating G protein-coupled receptor signaling pathway
Pilomotor reflex
Positive regulation of action potential
Positive regulation of cardiac muscle contraction
Positive regulation of cardiac muscle hypertrophy
Positive regulation of cytosolic calcium ion concentration
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of heart rate by epinephrine-norepinephrine
Positive regulation of MAPK cascade
Positive regulation of non-membrane spanning protein tyrosine kinase activity
Positive regulation of protein kinase C signaling
Positive regulation of smooth muscle contraction
Positive regulation of synaptic transmission, GABAergic
Positive regulation of systemic arterial blood pressure
Positive regulation of the force of heart contraction by epinephrine-norepinephrine
Positive regulation of vasoconstriction
Regulation of synaptic vesicle exocytosis
Response to drug
Response to hormone
Signal transduction
Smooth muscle contraction

Cytoplasm; Cell membrane; Nucleus membrane; Caveola. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Extracellular: 1-27 aa
Helical: 28-51 aa
Cytoplasmic: 52-64 aa
Helical: 65-88 aa
Extracellular: 89-99 aa
Helical: 100-122 aa
Cytoplasmic: 123-143 aa
Helical: 144-167 aa
Extracellular: 168-181 aa
Helical: 182-205 aa
Cytoplasmic: 206-273 aa
Helical: 274-297 aa
Extracellular: 298-305 aa
Helical: 306-329 aa
Cytoplasmic: 330-466 aa

C-terminal Ser or Thr residues may be phosphorylated.