AGTPBP1

NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM
Full Name
ATP/GTP binding protein 1
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Biological Process
Cerebellar Purkinje cell differentiation
C-terminal protein deglutamylation
Eye photoreceptor cell differentiation
Mitochondrion organization
Neuromuscular process
Olfactory bulb development
Protein deglutamylation
Protein side chain deglutamylation
Cellular Location
Cytoplasm; Cytosol; Nucleus; Mitochondrion. Localizes in both the cytoplasm and nuclei of interphase and dividing cells.
Involvement in disease
Neurodegeneration, childhood-onset, with cerebellar atrophy (CONDCA): An autosomal recessive disorder characterized by early onset of progressive neurodegeneration affecting the central and peripheral nervous systems. Clinical features include global developmental delay, impaired intellectual development, poor or absent speech, and motor abnormalities. Brain imaging shows cerebellar atrophy. Death in childhood may occur.
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Anti-AGTPBP1 antibodies

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Mouse Anti-AGTPBP1 Recombinant Antibody (V2-180246) (CBMAB-A1675-YC)

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Target: AGTPBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180246
Application*: E, WB
Datasheet SDS

Mouse Anti-AGTPBP1 Recombinant Antibody (V2-175279) (CBMAB-N0616-WJ)

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Target: AGTPBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-175279
Application*: F, WB
Datasheet SDS

Mouse Anti-AGTPBP1 Recombinant Antibody (V2-175278) (CBMAB-N0615-WJ)

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Target: AGTPBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-175278
Application*: P, WB
Datasheet SDS

Mouse Anti-AGTPBP1 Recombinant Antibody (V2-175277) (CBMAB-N0614-WJ)

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Target: AGTPBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-175277
Application*: WB
Datasheet SDS

Mouse Anti-AGTPBP1 Recombinant Antibody (V2-174732) (CBMAB-N4370-WJ)

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Target: AGTPBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-174732
Application*: WB, IP, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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