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Mouse Anti-AGTPBP1 Recombinant Antibody (V2-175277) (CBMAB-N0614-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-175277
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 368-753 of human AGTPBP1 (NP_056054) produced in E.coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP/GTP binding protein 1
Introduction
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]
Entrez Gene ID
23287
UniProt ID
Q9UPW5
Alternative Names
ATP/GTP Binding Protein 1; Nervous System Nuclear Protein Induced By Axotomy Protein 1 Homolog; Tubulinyl-Tyr Carboxypeptidase; Cytosolic Carboxypeptidase 1; Tyrosine Carboxypeptidase; Carboxypeptidase-Tubulin; Soluble Carboxypeptidase;
Function
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Biological Process
Cerebellar Purkinje cell differentiation
C-terminal protein deglutamylation
Eye photoreceptor cell differentiation
Mitochondrion organization
Neuromuscular process
Olfactory bulb development
Protein deglutamylation
Protein side chain deglutamylation
Cellular Location
Cytoplasm; Cytosol; Nucleus; Mitochondrion. Localizes in both the cytoplasm and nuclei of interphase and dividing cells.
Involvement in disease
Neurodegeneration, childhood-onset, with cerebellar atrophy (CONDCA): An autosomal recessive disorder characterized by early onset of progressive neurodegeneration affecting the central and peripheral nervous systems. Clinical features include global developmental delay, impaired intellectual development, poor or absent speech, and motor abnormalities. Brain imaging shows cerebellar atrophy. Death in childhood may occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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