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AK1

This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Full Name

adenylate kinase 1

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Biological Process

ADP biosynthetic process Source: UniProtKB-UniRule
AMP metabolic process Source: UniProtKB-UniRule
ATP metabolic process Source: UniProtKB-UniRule
Nucleobase-containing small molecule interconversion Source: Reactome
Nucleoside diphosphate phosphorylation Source: UniProtKB
Nucleoside triphosphate biosynthetic process Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Hemolytic anemia due to adenylate kinase deficiency (HAAKD): A disease characterized by hemolytic anemia and undetectable erythrocyte adenylate kinase activity.

Anti-AK1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-AK1 Recombinant Antibody (V2-180383) (CBMAB-A1855-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180383

Application*: E, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180381) (CBMAB-A1853-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-180381

Application*: E, IC, IF, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180380) (CBMAB-A1852-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-180380

Application*: E, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180378) (CBMAB-A1850-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: V2-180378

Application*: E, IF, IP, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180377) (CBMAB-A1849-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180377

Application*: E, IF, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180376) (CBMAB-A1848-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180376

Application*: E, IF, IP, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180375) (CBMAB-A1847-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: V2-180375

Application*: F, IC, IF, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180374) (CBMAB-A1846-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: V2-180374

Application*: F, IC, IF, WB

Mouse Anti-AK1 Recombinant Antibody (V2-180373) (CBMAB-A1845-YC)

SDS

Target: AK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: V2-180373

Application*: F, IC, IF, WB

AK1 Matched Antibody Pair (050) (APMAB-050LY)

SDS

Target: AK1

Specificity: Human

AK1 Matched Antibody Pair (049) (APMAB-049LY)

SDS

Target: AK1

Specificity: Human

AK1 Matched Antibody Pair (048) (APMAB-048LY)

SDS

Target: AK1

Specificity: Human

AK1 Matched Antibody Pair (047) (APMAB-047LY)

SDS

Target: AK1

Specificity: Human

AK1 Matched Antibody Pair (046) (APMAB-046LY)

SDS

Target: AK1

Specificity: Human

AK1 Matched Antibody Pair (045) (APMAB-045LY)

SDS

Target: AK1

Specificity: Human

AK1 Matched Antibody Pair (044) (APMAB-044LY)

SDS

Target: AK1

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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