AKAP6

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq]

Full Name

A kinase (PRKA) anchor protein 6

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

Biological Process

Action potential Source: BHF-UCL
cAMP-mediated signaling Source: BHF-UCL
Cellular response to cAMP Source: BHF-UCL
Cellular response to cytokine stimulus Source: BHF-UCL
Positive regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Positive regulation of cell growth Source: BHF-UCL
Positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
Positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
Positive regulation of potassium ion transmembrane transport Source: BHF-UCL
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Protein targeting Source: UniProtKB
Regulation of membrane repolarization Source: BHF-UCL
Regulation of protein kinase A signaling Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL

Cellular Location

Nucleus membrane; Sarcoplasmic reticulum. In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.