Mouse Anti-AKAP6 Recombinant Antibody (V2-611078) (CBMAB-A0231-LY)

Name: Mouse Anti-AKAP6 Recombinant Antibody (V2-611078)
SKU: CBMAB-A0231-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-611078

Application

WB, ELISA

Immunogen

AKAP6 (NP_004265.3, 2221 a.a. ~ 2318 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1-5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

A kinase (PRKA) anchor protein 6

Introduction

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq]

Entrez Gene ID

9472

UniProt ID

Q13023

Alternative Names

ADAP100; ADAP6; AKAP100; KIAA0311; MGC165020; PRKA6; mAKAP

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.

Biological Process

Action potential Source: BHF-UCL
cAMP-mediated signaling Source: BHF-UCL
Cellular response to cAMP Source: BHF-UCL
Cellular response to cytokine stimulus Source: BHF-UCL
Positive regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
Positive regulation of cell growth Source: BHF-UCL
Positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
Positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
Positive regulation of potassium ion transmembrane transport Source: BHF-UCL
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Protein targeting Source: UniProtKB
Regulation of membrane repolarization Source: BHF-UCL
Regulation of protein kinase A signaling Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL

Cellular Location

Nucleus membrane; Sarcoplasmic reticulum. In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.

Hakem Zadeh, F., Teng, A. C., Kuzmanov, U., Chambers, P. J., Tupling, A. R., & Gramolini, A. O. (2019). AKAP6 and phospholamban colocalize and interact in HEK‐293T cells and primary murine cardiomyocytes. Physiological reports, 7(14), e14144.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-AKAP6 Recombinant Antibody (V2-611077) (CAT#: CBMAB-A0230-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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