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AKR7A2

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Full Name

Aldo-Keto Reductase Family 7 Member A2

Function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Biological Process

Aflatoxin metabolic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Cellular aldehyde metabolic process Source: ProtInc
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process

Cellular Location

Cytoplasm; Golgi apparatus

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Anti-AKR7A2 antibodies

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Mouse Anti-AKR7A2 Recombinant Antibody (V2-180487) (CBMAB-A2002-YC)

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Target: AKR7A2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180487

Application*: E, IP, WB

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180486) (CBMAB-A2001-YC)

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Target: AKR7A2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Zebrafish

Clone: V2-180486

Application*: WB, P, IF, IC

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180485) (CBMAB-A2000-YC)

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Target: AKR7A2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180485

Application*: E, IP, WB

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180484) (CBMAB-A1999-YC)

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Target: AKR7A2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180484

Application*: E, WB

AKR7A2 Matched Antibody Pair (057) (APMAB-057LY)

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Target: AKR7A2

Specificity: Human

AKR7A2 Matched Antibody Pair (056) (APMAB-056LY)

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Target: AKR7A2

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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