AKR7A2

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Full Name
Aldo-Keto Reductase Family 7 Member A2
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Biological Process
Aflatoxin metabolic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Cellular aldehyde metabolic process Source: ProtInc
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process
Cellular Location
Cytoplasm; Golgi apparatus
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Anti-AKR7A2 antibodies

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Mouse Anti-AKR7A2 Recombinant Antibody (V2-180487) (CBMAB-A2002-YC)

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Target: AKR7A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180487
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180486) (CBMAB-A2001-YC)

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Target: AKR7A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Zebrafish
Clone: V2-180486
Application*: WB, P, IF, IC
Datasheet SDS

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180485) (CBMAB-A2000-YC)

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Target: AKR7A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180485
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-AKR7A2 Recombinant Antibody (V2-180484) (CBMAB-A1999-YC)

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Target: AKR7A2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180484
Application*: E, WB
Datasheet SDS

AKR7A2 Matched Antibody Pair (057) (APMAB-057LY)

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Target: AKR7A2
Specificity: Human
Datasheet SDS

AKR7A2 Matched Antibody Pair (056) (APMAB-056LY)

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Target: AKR7A2
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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