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Mouse Anti-AKR7A2 Recombinant Antibody (V2-180485) (CBMAB-A2000-YC)

Provided herein is a Mouse monoclonal antibody against Human Aldo-Keto Reductase Family 7 Member A2. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all AKR7A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180485
Antibody Isotype
IgG1, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
AKR7A2 (AAH10852. 1, 1-330 aa) full-length recombinant protein with GST tag. Immunogen sequence: MSRPPPPRVA SVLGTMEMGR RMDAPASAAA VRAFLERGHT ELDTAFMYSD GQSETILGGL GLGLGGGDCR VKIATKANPW DGKSLKPDSV RSQLETSLKR LQCPQVDLFY LHAPDHGTPV EETLHACQRL HQEGKFVELG LSNYASWEVA EICTLCKSNG WILPTVYQGM YNATTRQVET ELFPCLRHFG LRFYAYNPLA GGLLTGKYKY EDKDGKQPVG RFFGNSWAET YRNRFWKEHH FEAIALVEKA LQAAYGASAP SVTSAALRWM YHHSQLQGAH GDAVILGMSS LEQLEQNLAA TEEGPLEPAV VDAFNQAWHL VAHECPNYFR
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-330

Target

Full Name
Aldo-Keto Reductase Family 7 Member A2
Introduction
AKR7A2 belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, t
Entrez Gene ID
8574
UniProt ID
O43488
Alternative Names
Aldo-Keto Reductase Family 7 Member A2; Succinic Semialdehyde Reductase; Aflatoxin Aldehyde Reductase; AFB1 Aldehyde Reductase 1; Aldoketoreductase 7; SSA Reductase; AFB1-AR 1; AFAR1; AFAR;
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Biological Process
Aflatoxin metabolic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Cellular aldehyde metabolic process Source: ProtInc
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process
Cellular Location
Cytoplasm; Golgi apparatus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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