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ALB

This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metabolites, as well as exogenous drugs. Additionally, this protein exhibits an esterase-like activity with broad substrate specificity. The encoded preproprotein is proteolytically processed to generate the mature protein. A peptide derived from this protein, EPI-X4, is an endogenous inhibitor of the CXCR4 chemokine receptor. [provided by RefSeq, Jul 2016]
Full Name
Albumin
Function
Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc> calcium> magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017).
Biological Process
Cellular protein metabolic process Source: Reactome
Cellular response to starvation Source: UniProtKB
Heme biosynthetic process Source: Reactome
Heme catabolic process Source: Reactome
High-density lipoprotein particle remodeling Source: Reactome
Maintenance of mitochondrion location Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of programmed cell death Source: UniProtKB
Platelet degranulation Source: Reactome
Post-translational protein modification Source: Reactome
Receptor-mediated endocytosis Source: Reactome
Retina homeostasis Source: UniProtKB
Cellular Location
Secreted
Involvement in disease
Hyperthyroxinemia, familial dysalbuminemic (FDAH): A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity.
Analbuminemia (ANALBA): A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides.
PTM
Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylated by FAM20C in the extracellular medium.
Acetylated on Lys-223 by acetylsalicylic acid.

Anti-ALB antibodies

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Target: ALB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-364091
Application*: E
Target: ALB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-180650
Application*: WB, IP
Target: ALB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-180668
Application*: E
Target: ALB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Rat
Clone: V2-55272
Application*: IC, IF, WB, IP, E, P
Target: ALB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180607
Application*: E, IF, WB, IP, FC
Target: ALB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-180616
Application*: WB, E
Target: ALB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180623
Application*: E, IH, IP, WB
Target: ALB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle
Clone: V2-611124
Application*: WB, E
Target: ALB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-54882
Application*: IC, IF, WB, IP, E, P
Target: ALB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-363290
Application*: WB, P, IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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