AMTN

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, includin
Full Name
Amelotin
Function
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
Biological Process
Biomineral tissue development Source: UniProtKB-KW
Cell adhesion Source: UniProtKB-KW
Cellular protein metabolic process Source: Reactome
Odontogenesis of dentin-containing tooth Source: HGNC-UCL
Positive regulation of biomineral tissue development Source: UniProtKB
Positive regulation of enamel mineralization Source: GO_Central
Post-translational protein modification Source: Reactome
Cellular Location
Secreted
Involvement in disease
Amelogenesis imperfecta 3B (AI3B): An autosomal dominant form of amelogenesis imperfecta, a defect of enamel formation. AI3B is characterized by hypomineralized enamel that has reduced tickness and exhibits structural defects.
PTM
Phosphorylated by FAM20C in vitro.
O-glycosylated.
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Anti-AMTN antibodies

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Mouse Anti-AMTN Recombinant Antibody (1C11) (CBMAB-A2593-YC)

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Target: AMTN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C11
Application*: IH, WB
Datasheet SDS

Mouse Anti-AMTN Recombinant Antibody (2D9) (CBMAB-A2597-YC)

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Target: AMTN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D9
Application*: WB, IH
Datasheet SDS

Human AMTN ELISA Kit (V2LY-0626-LY4339)

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Target: AMTN
Sensitivity: 0.026 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant AMTN protein, Fc Tag (V2LY-0526-LY2069)

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Target: AMTN
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-209
Tag: Fc Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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