AP1AR

Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.

Full Name

Adaptor Related Protein Complex 1 Associated Regulatory Protein

Function

Biological Process

Cellular protein localization Source: Ensembl
Negative regulation of cell motility Source: Ensembl
Negative regulation of receptor recycling Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: MGI
Protein transport Source: UniProtKB-KW
Regulation of Arp2/3 complex-mediated actin nucleation Source: Ensembl
Vesicle targeting, trans-Golgi to endosome Source: UniProtKB

Cellular Location

Late endosome; Early endosome; trans-Golgi network. Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.

PTM

Palmitoylated.