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ARAF

This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

Full Name

A-Raf Proto-Oncogene, Serine/Threonine Kinase

Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Biological Process

Cellular protein modification process Source: ProtInc
MAPK cascade Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
Regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of TOR signaling Source: UniProtKB

Cellular Location

Cytosol; Mitochondrion

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Anti-ARAF antibodies

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Mouse Anti-ARAF Recombinant Antibody (3G2) (CBMAB-A0442-LY)

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Target: ARAF

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G2

Application*: WB, E

Mouse Anti-ARAF Recombinant Antibody (CBYC-A732) (CBMAB-A3400-YC)

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Target: ARAF

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-A732

Application*: E, WB

Mouse Anti-ARAF Recombinant Antibody (6H6) (CBMAB-A3394-YC)

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Target: ARAF

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6H6

Application*: E, WB

Mouse Anti-ARAF Recombinant Antibody (A5) (CBMAB-A3393-YC)

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Target: ARAF

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: A5

Application*: E, WB, IF, IP

Human Recombinant ARAF protein, GST Tag (V2LY-0526-LY2160)

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Target: ARAF

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 209-end

Tag: GST Tag

Rabbit Anti-ARAF Recombinant Antibody (EG216) (CBMAB-EN243-LY)

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Target: ARAF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG216

Application*: WB, IH

Rabbit Anti-ARAF Recombinant Antibody (D2P9P) (CBMAB-CP2190-LY)

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Target: ARAF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: D2P9P

Application*: WB, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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