ARG2

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq]

arginase, type II

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells (PubMed:27745970).
May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549).
May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity).
In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294).
Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666).
Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082).
Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324).
Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).

Adaptive immune response Source: UniProtKB-KW
Arginine catabolic process to ornithine Source: GO_Central
Innate immune response Source: UniProtKB-KW
Negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process Source: Ensembl
Negative regulation of CD4-positive, alpha-beta T cell proliferation Source: Ensembl
Negative regulation of chemokine (C-C motif) ligand 4 production Source: Ensembl
Negative regulation of chemokine (C-C motif) ligand 5 production Source: Ensembl
Negative regulation of defense response to bacterium Source: Ensembl
Negative regulation of interleukin-13 production Source: Ensembl
Negative regulation of interleukin-17 production Source: Ensembl
Negative regulation of macrophage inflammatory protein 1 alpha production Source: Ensembl
Negative regulation of tumor necrosis factor production Source: UniProtKB
Negative regulation of type 2 immune response Source: Ensembl
Nitric oxide biosynthetic process Source: ProtInc
Positive regulation of cellular senescence Source: UniProtKB
Regulation of interleukin-1 beta production Source: Ensembl
Regulation of reactive oxygen species biosynthetic process Source: Ensembl
Striated muscle contraction Source: Ensembl
Urea cycle Source: Reactome
Ureteric bud development Source: Ensembl

Mitochondrion