ARHGAP6

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Full Name

Rho GTPase activating protein 6

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.

Biological Process

Actin filament polymerization Source: UniProtKB
Activation of phospholipase C activity Source: BHF-UCL
Focal adhesion assembly Source: Ensembl
Negative regulation of focal adhesion assembly Source: BHF-UCL
Negative regulation of stress fiber assembly Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of phospholipase activity Source: BHF-UCL
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: ProtInc

Cellular Location

Cytoplasm