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Mouse Anti-ARHGAP6 Recombinant Antibody (CBCNA-008) (CBMAB-R0410-CN)


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Published Data
Mouse Anti-ARHGAP6 Recombinant Antibody (CBCNA-008) CBMAB-R0410-CN in WB
Western blot analysis of whole cell extracts from transfected CHO cells: 2 μgs of ARHGAP were transfected with 4 μgs of a carrier cDNA (GFP-Ire vector, lane 1), 4 μgs of shRNA directed against ARHGAP6 (lane 2), or 4 μgs of the scrambled shRNA control (i.e., the same nucleotide composition but in random order; lane 3). Two days post transfection, whole cell extracts were prepared and analyzed by Western Blot. ...View More
Potet, F., Petersen, C. I., Boutaud, O., Shuai, W., Stepanovic, S. Z., Balser, J. R., & Kupershmidt, S. (2009). Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator. Journal of molecular and cellular cardiology, 46(2), 257-267.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNA-008
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ARHGAP6 (NP_038286, aa. 531-636) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent

Target

Full Name
Rho GTPase activating protein 6
Introduction
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
395
UniProt ID
O43182
Alternative Names
Rho GTPase Activating Protein 6; Rho-Type GTPase-Activating Protein RhoGAPX-1; Rho-Type GTPase-Activating Protein 6; RHOGAP6; Rho GTPase-Activating Protein 6; RHOGAPX-1;
Function
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.
Biological Process
Actin filament polymerization Source: UniProtKB
Activation of phospholipase C activity Source: BHF-UCL
Focal adhesion assembly Source: Ensembl
Negative regulation of focal adhesion assembly Source: BHF-UCL
Negative regulation of stress fiber assembly Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of phospholipase activity Source: BHF-UCL
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: ProtInc
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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