Mouse Anti-ARHGAP6 Recombinant Antibody (CBCNA-008) (CBMAB-R0410-CN)

Name: Mouse Anti-ARHGAP6 Recombinant Antibody (CBCNA-008)
SKU: CBMAB-R0410-CN
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-ARHGAP6 Recombinant Antibody (CBCNA-008) CBMAB-R0410-CN in WB

Western blot analysis of whole cell extracts from transfected CHO cells: 2 μgs of ARHGAP were transfected with 4 μgs of a carrier cDNA (GFP-Ire vector, lane 1), 4 μgs of shRNA directed against ARHGAP6 (lane 2), or 4 μgs of the scrambled shRNA control (i.e., the same nucleotide composition but in random order; lane 3). Two days post transfection, whole cell extracts were prepared and analyzed by Western Blot. ...View More

Potet, F., Petersen, C. I., Boutaud, O., Shuai, W., Stepanovic, S. Z., Balser, J. R., & Kupershmidt, S. (2009). Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator. Journal of molecular and cellular cardiology, 46(2), 257-267.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNA-008

Application

ELISA, WB

Immunogen

ARHGAP6 (NP_038286, aa. 531-636) partial recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

More Infomation

Target

Full Name

Rho GTPase activating protein 6

Introduction

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

395

UniProt ID

O43182

Alternative Names

Rho GTPase Activating Protein 6; Rho-Type GTPase-Activating Protein RhoGAPX-1; Rho-Type GTPase-Activating Protein 6; RHOGAP6; Rho GTPase-Activating Protein 6; RHOGAPX-1;

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.

Biological Process

Actin filament polymerization Source: UniProtKB
Activation of phospholipase C activity Source: BHF-UCL
Focal adhesion assembly Source: Ensembl
Negative regulation of focal adhesion assembly Source: BHF-UCL
Negative regulation of stress fiber assembly Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of phospholipase activity Source: BHF-UCL
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: ProtInc

Cellular Location

Cytoplasm

Mamoor, S. (2021). Differential expression of Rho GTPase activating protein 6 in human epithelial ovarian cancer.

Li, P., Lv, H., Xu, M., Zang, B., & Ma, Y. (2020). ARHGAP6 Promotes Apoptosis and Inhibits Glycolysis in Lung Adenocarcinoma Through STAT3 Signaling Pathway. Cancer Management and Research, 12, 9665.

Wu, Y., Xu, M., He, R., Xu, K., & Ma, Y. (2019). ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells. Oncology reports, 41(4), 2281-2888.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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