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Mouse Anti-ARHGAP6 Recombinant Antibody (1G5) (CBMAB-A0457-LY)

The product is antibody recognizes ARHGAP6. The antibody 1G5 immunoassay techniques such as: WB, ELISA.
See all ARHGAP6 antibodies
Published Data
Fig. 1 ARHGAP6 is present in human spermatozoa as revealed by immunoblots of the sperm lysate with specific anti-ARHGAP6 antibodies.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ARHGAP6 (NP_038286, 531 a.a. ~ 636 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rho GTPase activating protein 6
Introduction
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
395
UniProt ID
O43182
Alternative Names
RHOGAP6; RHOGAPX-1
Function
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology.
Biological Process
Actin filament polymerization Source: UniProtKB
Activation of phospholipase C activity Source: BHF-UCL
Focal adhesion assembly Source: Ensembl
Negative regulation of focal adhesion assembly Source: BHF-UCL
Negative regulation of stress fiber assembly Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of phospholipase activity Source: BHF-UCL
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: ProtInc
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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