ARHGEF5

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]

Full Name

Rho Guanine Nucleotide Exchange Factor 5

Function

Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624).
Strongly activates RHOA (PubMed:15601624).
Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity).
Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624).
Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653).
Required for SRC-induced podosome formation (By similarity).
Involved in positive regulation of immature dendritic cell migration (By similarity).

Biological Process

Activation of GTPase activity Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Intracellular signal transduction Source: InterPro
Positive regulation of apoptotic process Source: Reactome
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of JUN kinase activity Source: UniProtKB
Positive regulation of protein import Source: UniProtKB
Positive regulation of stress fiber assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cytoskeleton organization Source: UniProtKB
Regulation of GTPase activity Source: MGI
Regulation of small GTPase mediated signal transduction Source: Reactome

Cellular Location

Cytoplasm; Nucleus; Podosome

PTM

Activation of SRC induces tyrosine phosphorylation of ARHGEF5.