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Mouse Anti-ARHGEF5 Recombinant Antibody (3A12-B5) (CBMAB-A0470-LY)

The product is antibody recognizes ARHGEF5. The antibody 3A12-B5 immunoassay techniques such as: WB, ELISA.
See all ARHGEF5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A12-B5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ARHGEF5 (AAH14555, 1 a.a. ~ 519 a.a) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rho Guanine Nucleotide Exchange Factor 5
Introduction
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq]
Entrez Gene ID
7984
UniProt ID
Q12774
Alternative Names
DKFZp686N1969; GEF5; P60; TIM; TIM1
Function
Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624).
Strongly activates RHOA (PubMed:15601624).
Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity).
Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624).
Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653).
Required for SRC-induced podosome formation (By similarity).
Involved in positive regulation of immature dendritic cell migration (By similarity).
Biological Process
Activation of GTPase activity Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Intracellular signal transduction Source: InterPro
Positive regulation of apoptotic process Source: Reactome
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of JUN kinase activity Source: UniProtKB
Positive regulation of protein import Source: UniProtKB
Positive regulation of stress fiber assembly Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cytoskeleton organization Source: UniProtKB
Regulation of GTPase activity Source: MGI
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Cytoplasm; Nucleus; Podosome
PTM
Activation of SRC induces tyrosine phosphorylation of ARHGEF5.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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