ARMCX1

This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008]

Full Name

Armadillo Repeat Containing, X-Linked 1

Function

Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.

Biological Process

Hematopoietic stem cell homeostasis Source: Ensembl

Cellular Location

Mitochondrion; Mitochondrion outer membrane

Topology

Mitochondrial intermembrane: 1-6 aa
Helical: 7-29 aa
Cytoplasmic: 30-453 aa