ASB4

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq]

Full Name

ankyrin repeat and SOCS box-containing 4

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

Biological Process

Intracellular signal transduction Source: InterPro
Positive regulation of vasculogenesis Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein autoubiquitination Source: UniProtKB

Cellular Location

Cytosol; Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex

PTM

Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.