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Mouse Anti-ASB4 Recombinant Antibody (2G11) (CBMAB-A0526-LY)

The product is antibody recognizes ASB4. The antibody 2G11 immunoassay techniques such as: ELISA.
See all ASB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G11
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
ASB4 (NP_057200, 295 a.a. ~ 403 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ankyrin repeat and SOCS box-containing 4
Introduction
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq]
Entrez Gene ID
51666
UniProt ID
Q9Y574
Alternative Names
ASB-4; MGC142039; MGC142041
Function
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).
Biological Process
Intracellular signal transduction Source: InterPro
Positive regulation of vasculogenesis Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein autoubiquitination Source: UniProtKB
Cellular Location
Cytosol; Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex
PTM
Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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