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ATG12

Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]
Full Name
Autophagy Related 12
Function
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
(Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747).
Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).
Biological Process
Autophagosome assembly Source: UniProtKB
Autophagy of mitochondrion Source: GO_Central
Autophagy of nucleus Source: GO_Central
C-terminal protein lipidation Source: GO_Central
Macroautophagy Source: Reactome
Viral process Source: UniProtKB-KW
Cellular Location
Cytoplasm; Preautophagosomal structure membrane. TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
PTM
Acetylated by EP300.
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Anti-ATG12 antibodies

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Mouse Anti-ATG12 Recombinant Antibody (CAP191) (CBMAB-AP460LY)

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Target: ATG12
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CAP191
Application*: IF, WB
Datasheet SDS

Mouse Anti-ATG12 Recombinant Antibody (2H8) (CBMAB-A0571-LY)

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Target: ATG12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H8
Application*: WB, E
Datasheet SDS

Mouse Anti-ATG12 Recombinant Antibody (CBYC-A850) (CBMAB-A3900-YC)

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Target: ATG12
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYC-A850
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-ATG12 Recombinant Antibody (CBYC-A849) (CBMAB-A3899-YC)

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Target: ATG12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A849
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-ATG12 Recombinant Antibody (CBYC-A848) (CBMAB-A3898-YC)

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Target: ATG12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYC-A848
Application*: IF, WB, IP
Datasheet SDS

Rabbit Anti-ATG12 Recombinant Antibody (A3894) (CBMAB-A3894-YC)

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Target: ATG12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A3894
Application*: IC, IF, WB
Datasheet SDS

Rabbit Anti-ATG12 Recombinant Antibody (CBNH-007) (CBMAB-R4332-CN)

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Target: ATG12
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: CBNH-007
Application*: IP, WB, IF. IH
Datasheet SDS

Mouse Anti-ATG12 Recombinant Antibody (1F9) (CBMAB-1158-CN)

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Target: ATG12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: WB, E
Datasheet SDS

Mouse Anti-ATG12 Recombinant Antibody (43CT73.3.5.5.4) (CBMAB-0109CQ)

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Target: ATG12
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 43CT73.3.5.5.4
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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