AURKC

AURKC is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relati

Full Name

Aurora Kinase C

Function

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Biological Process

Attachment of spindle microtubules to kinetochore Source: UniProtKB
Cell division Source: UniProtKB-KW
Histone modification Source: UniProtKB
Meiotic cell cycle Source: UniProtKB-KW
Mitotic spindle midzone assembly Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Oocyte development Source: InterPro
Positive regulation of cytokinesis Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cytokinesis Source: GO_Central
Spermatogenesis Source: InterPro

Cellular Location

Nucleus; Spindle; Chromosome; Centromere. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Involvement in disease

Spermatogenic failure 5 (SPGF5): An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.