Mouse Anti-AURKC Recombinant Antibody (2B7) (CBMAB-A4204-YC)

Name: Mouse Anti-AURKC Recombinant Antibody (2B7)
SKU: CBMAB-A4204-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B7

Application

Immunogen

Protein expressed in 293T cell transfected with human AURKC expression vector.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:200-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Aurora Kinase C

Introduction

AURKC is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relati

Entrez Gene ID

6795

UniProt ID

Q9UQB9

Alternative Names

Aurora Kinase C; Serine/Threonine Kinase 13 (Aurora/IPL1-Like); Serine/Threonine-Protein Kinase Aurora-C; Serine/Threonine-Protein Kinase 13; Aurora/IPL1-Related Kinase 3; Aurora-Related Kinase 3; EC 2.7.11.1; Aurora 3; STK13; ARK-3; AIE2; AIK3;

Function

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Biological Process

Attachment of spindle microtubules to kinetochore Source: UniProtKB
Cell division Source: UniProtKB-KW
Histone modification Source: UniProtKB
Meiotic cell cycle Source: UniProtKB-KW
Mitotic spindle midzone assembly Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Oocyte development Source: InterPro
Positive regulation of cytokinesis Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cytokinesis Source: GO_Central
Spermatogenesis Source: InterPro

Cellular Location

Nucleus; Spindle; Chromosome; Centromere. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Involvement in disease

Spermatogenic failure 5 (SPGF5): An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.

Bejar, J. F., DiSanza, Z., & Quartuccio, S. M. (2021). The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells. Experimental Cell Research, 112803.

Hamza, L., Gaitch, N., Sallem, A., Boucekkine, N., Girodon, E., Oumeziane, A., ... & Bienvenu, T. (2020). Two frequent loss‐of‐function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia. Andrologia, 52(11), e13868.

Kobesiy, M. M., Foda, B. M., Ali, O. S., Fahmy, I., & Ismail, S. M. (2020). Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia. Andrologia, 52(7), e13619.

Bejar, J. (2020). Effects of Aurora Kinase C Expression on Retina Pigmented Epithelial Cell Migration, Proliferation, and Anchorage Independent Growth.

Azeez, K. R. A., Chatterjee, S., Yu, C., Golub, T. R., Sobott, F., & Elkins, J. M. (2019). Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nature communications, 10(1), 1-11.

Nguyen, A. L., Drutovic, D., Vazquez, B. N., El Yakoubi, W., Gentilello, A. S., Malumbres, M., ... & Schindler, K. (2018). Genetic interactions between the aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Current Biology, 28(21), 3458-3468.

Li, W., Wang, P., Zhang, B., Zhang, J., Ming, J., Xie, W., & Na, J. (2017). Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. Protein & cell, 8(9), 662-674.

Nguyen, A. L., Marin, D., Zhou, A., Gentilello, A. S., Smoak, E. M., Cao, Z., ... & Schindler, K. (2017). Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy. MHR: Basic science of reproductive medicine, 23(6), 406-416.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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