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Mouse Anti-AURKC Recombinant Antibody (10A7) (CBMAB-A4203-YC)

Provided herein is a Mouse monoclonal antibody against Human Aurora Kinase C. The antibody can be used for immunoassay techniques, such as ICC, IF, IHC, IHC-P, WB.
See all AURKC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10A7
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Protein expressed in 293T cell transfected with human AURKC expression vector.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:100
WB1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aurora Kinase C
Introduction
AURKC is a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relati
Entrez Gene ID
6795
UniProt ID
Q9UQB9
Alternative Names
Aurora Kinase C; Serine/Threonine Kinase 13 (Aurora/IPL1-Like); Serine/Threonine-Protein Kinase Aurora-C; Serine/Threonine-Protein Kinase 13; Aurora/IPL1-Related Kinase 3; Aurora-Related Kinase 3; EC 2.7.11.1; Aurora 3; STK13; ARK-3; AIE2; AIK3;
Function
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Biological Process
Attachment of spindle microtubules to kinetochore Source: UniProtKB
Cell division Source: UniProtKB-KW
Histone modification Source: UniProtKB
Meiotic cell cycle Source: UniProtKB-KW
Mitotic spindle midzone assembly Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Oocyte development Source: InterPro
Positive regulation of cytokinesis Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cytokinesis Source: GO_Central
Spermatogenesis Source: InterPro
Cellular Location
Nucleus; Spindle; Chromosome; Centromere. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Involvement in disease
Spermatogenic failure 5 (SPGF5): An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.

Bejar, J. F., DiSanza, Z., & Quartuccio, S. M. (2021). The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells. Experimental Cell Research, 112803.

Hamza, L., Gaitch, N., Sallem, A., Boucekkine, N., Girodon, E., Oumeziane, A., ... & Bienvenu, T. (2020). Two frequent loss‐of‐function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia. Andrologia, 52(11), e13868.

Kobesiy, M. M., Foda, B. M., Ali, O. S., Fahmy, I., & Ismail, S. M. (2020). Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia. Andrologia, 52(7), e13619.

Bejar, J. (2020). Effects of Aurora Kinase C Expression on Retina Pigmented Epithelial Cell Migration, Proliferation, and Anchorage Independent Growth.

Azeez, K. R. A., Chatterjee, S., Yu, C., Golub, T. R., Sobott, F., & Elkins, J. M. (2019). Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nature communications, 10(1), 1-11.

Nguyen, A. L., Drutovic, D., Vazquez, B. N., El Yakoubi, W., Gentilello, A. S., Malumbres, M., ... & Schindler, K. (2018). Genetic interactions between the aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Current Biology, 28(21), 3458-3468.

Li, W., Wang, P., Zhang, B., Zhang, J., Ming, J., Xie, W., & Na, J. (2017). Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. Protein & cell, 8(9), 662-674.

Nguyen, A. L., Marin, D., Zhou, A., Gentilello, A. S., Smoak, E. M., Cao, Z., ... & Schindler, K. (2017). Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy. MHR: Basic science of reproductive medicine, 23(6), 406-416.

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For research use only. Not intended for any clinical use.

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