Human Recombinant AURKC protein, GST Tag (V2LY-0526-LY2207)

Name: Human Recombinant AURKC protein, GST Tag
SKU: V2LY-0526-LY2207
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant AURKC protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 61 kDa.

Molecule Mass

61 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Aurora Kinase C

Function

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Biological Process

Attachment of spindle microtubules to kinetochore Source: UniProtKB
Cell division Source: UniProtKB-KW
Histone modification Source: UniProtKB
Meiotic cell cycle Source: UniProtKB-KW
Mitotic spindle midzone assembly Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Oocyte development Source: InterPro
Positive regulation of cytokinesis Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of cytokinesis Source: GO_Central
Spermatogenesis Source: InterPro

Cellular Location

Nucleus; Spindle; Chromosome; Centromere. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

Involvement in disease

Spermatogenic failure 5 (SPGF5): An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.

Bejar, J. F., DiSanza, Z., & Quartuccio, S. M. (2021). The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells. Experimental Cell Research, 112803.

Hamza, L., Gaitch, N., Sallem, A., Boucekkine, N., Girodon, E., Oumeziane, A., ... & Bienvenu, T. (2020). Two frequent loss‐of‐function mutations in Aurora Kinase C gene in Algerian infertile men with macrozoospermia. Andrologia, 52(11), e13868.

Kobesiy, M. M., Foda, B. M., Ali, O. S., Fahmy, I., & Ismail, S. M. (2020). Mutational analysis of Aurora kinase C gene in Egyptian patients with macrozoospermia. Andrologia, 52(7), e13619.

Bejar, J. (2020). Effects of Aurora Kinase C Expression on Retina Pigmented Epithelial Cell Migration, Proliferation, and Anchorage Independent Growth.

Azeez, K. R. A., Chatterjee, S., Yu, C., Golub, T. R., Sobott, F., & Elkins, J. M. (2019). Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nature communications, 10(1), 1-11.

Nguyen, A. L., Drutovic, D., Vazquez, B. N., El Yakoubi, W., Gentilello, A. S., Malumbres, M., ... & Schindler, K. (2018). Genetic interactions between the aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis. Current Biology, 28(21), 3458-3468.

Li, W., Wang, P., Zhang, B., Zhang, J., Ming, J., Xie, W., & Na, J. (2017). Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos. Protein & cell, 8(9), 662-674.

Nguyen, A. L., Marin, D., Zhou, A., Gentilello, A. S., Smoak, E. M., Cao, Z., ... & Schindler, K. (2017). Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy. MHR: Basic science of reproductive medicine, 23(6), 406-416.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant AURKC, Active protein, GST Tag (CAT#: V2LY-0526-LY2208)

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Human Recombinant AURKC, Active protein, GST Tag (CAT#: V2LY-0526-LY2208)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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