BAG4

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq]

Full Name

BCL2-associated athanogene 4

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity).
Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.

Biological Process

Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: UniProtKB
Negative regulation of apoptotic process Source: ProtInc
Negative regulation of mRNA modification Source: Ensembl
Negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: Ensembl
Negative regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Positive regulation of actin filament polymerization Source: Ensembl
Positive regulation of cell adhesion Source: Ensembl
Positive regulation of fibroblast migration Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: Ensembl
Positive regulation of protein kinase B signaling Source: Ensembl
Positive regulation of stress fiber assembly Source: Ensembl
Protein folding Source: ProtInc
Protein localization to plasma membrane Source: Ensembl
Protein stabilization Source: GO_Central
Regulation of cellular response to heat Source: Reactome
Ruffle assembly Source: Ensembl
Tumor necrosis factor-mediated signaling pathway Source: Reactome

Cellular Location

Cytoplasm